Iron (II) and Zinc (II) complexes of gemifloxacin mesylate: synthesis, characterization, serum binding profiling, and evaluation of antimicrobial activity

Gemifloxacin mesylate is a synthetic fluoroquinolone derived antimicrobial agent. Two metal complexes of gemifloxacin were synthesized viz. gemifloxacin-Fe and gemifloxacin-Zn. The formed characterized by using TLC, TGA FT-IR spectra analyses. then evaluated for activity. newly two assessed against nine bacterial one fungal strain, where (30 µg/disc) was used as reference standard. new showed better activity than the standard drug Klebsiella pneumoniae among strains. But species, Acinetobacter lwoffii Enterococcus faecium, strain Candida albicans complete resistance to protein interaction with Bovine Serum Albumin (BSA) also studied. mechanism explored, suggesting that its Zn (II) complex interact BSA via static process while Fe interacts dynamic lower Ksv value indicated -BSA in ground-state. J. Bangladesh Acad. Sci. 46(2); 203-211: December 2022